Spectrum of monoclonal gammapathies in Andhra Pradesh

In the present study, monoclonal gammapathy was identified in a total of 245 patients of plasma cell dyscrasias during period of 1987 to 2000. The monoclonal band was identified in serum by agar gel electrophoresis in all the cases and in urine in a few cases. Characterization of paraprotein (monoclonal immunoglobulin class and light chain type) was carried out by employing immunoelectrophoresis and/or immunofixation electrophoresis using heavy chain specific gamma, alpha, mu, delta and epsilon and light chain specific kappa (K), lambda (λ) antisera. Serum immunoglobulins Ig G, Ig A, and Ig M were estimated by immunoturbidometry. Serum urea, creatinine, uric acid, alkaline phosphatase, total proteins, albumin, calcium and phosphorus were estimated by using routine biochemical methods. Among the 245 cases, 73.1% monoclonal gammapathies were of secretory type and 7.3% were non-secretory. Monoclonal gammapathies were associated with 80.4% of multiple myeloma, 8.9% of solitary plasmacytoma, 4.1% of extra-medullary plasmacytoma, 3.3% of lymphoma and 2.9% of plasma cell leukemia. Classification of secretory monoclonal immunoglobulin revealed monoclonal immunoglobulin Ig G in 74%, Ig A 15% and Ig M in 2.9% cases.     

Clinical utility of serum thyroglobulin in acute haemorrhage into the thyroid

Seven cases of suspected haemorrhage In pre-existing adenoma or cyst in the thyroid showed serum thyroglobulin (tg) levels phenomenonly elevated. The serum tg leveis reduced remarkably within one to three montha. During this period all patients were treated with thyroxin. It is concluded that serial serum thyroglobulin determinations may be useful in confirming the clinical suspicion of haemorrhage in the thyroid.     

Lipid peroxidation and antioxidant status in patients with rheumatoid arthritis

The changes in the erythrocyte lipid peroxidation products (MDA), levels of glutathione (GSH), ascorbic acid and plasma vitamin E (non enzymatic antioxidant parameters) and activities of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GP_X), catalase in erythrocytes and plasma glutathione - S - transferase (GST) activity were estimated in patients with rheumatoid arthritis. This work was undertaken to assess oxidative stress and anti oxidant status in patients with rheumatoid arthritis. It was observed that there was a significant increase in erythrocyte MDA levels, activities of SOD, GP_X, plasma GST and a significant decrease in erythrocyte GSH, ascorbic acid, plasma vitamin E levels and catalse activity in patients with rheumatoid arthritis when compared to controls. The results of our study suggests higher oxygen free radical production, evidenced by increased MDA and decreased GSH, ascorbic acid, vitamin E and Catalase activity, support to the oxidative stress in rheumatoid arthritis. The increased activities of antioxidant enzymes may be a compensatory regulation in response to increased oxidative stress.     

Ethnicity-based cultural differences in implicit managerial knowledge usage in three Australian organizations

This study was interested in determining whether ethnicity-based cultural differences affected knowledge usage in today's multicultural organizations. Our empirical study uses a psychology-based approach to measure what we refer to as implicit managerial knowledge of Information and Communication Technology (ICT) workers within three Australian organizations. The research instrument captures responses to various ICT workplace scenarios in order to determine and compare the different ways in which people make use of the implicit knowledge they use to manage themselves and others. Using the culture-based literature to assist with interpretation of the data, we have identified a number of themes and their characteristics and brought these together to provide a comprehensive model for understanding cultural influences. This model can be used to better appreciate why and perhaps anticipate how an individual's implicit managerial knowledge will be used in responding to everyday workplace situations. Such an understanding will assist organizations to develop appropriate and effective knowledge management strategies.     

Preliminary study on circulating serum levels of tumor necrosis factor—Alpha in patients of tuberculosis

Tumor necrosis factor-alpha (TNF-α) has been implicated in the pathogenesis of several non-infectious and infectious diseases including tuberculosis. In a prospective longitudinal study, TNF-α level in blood was estimated by sandwich ELISA using anti human TNF-α antibody, in 22 patients with active pleuro-pulmonary and lymphnode tuberculosis before and after chemotherapy and 8 healthy controls. Six patients and six controls had detectable levels (> 5 pg/ml) of TNF-α in blood. The mean TNF-α levels in controls and cases before and after treatment were 182.4pg/ml, 896.7 pg/ml and 678.7pg/ml pg/ml respectively. Though not statistically significant, there was a trend towards younger age, shorter duration of symptoms, presence of fever and anorexia, and high ESR, in patient with high serum TNF-α levels.     

Therapy in Parkinson’s disease: Some recent developments

Even though research is going on throughout the world, it is clear that at the present time there is really no cure for Parkinson’s disease. Treatment with drugs, with physiotherapy can slow down the progress of this disease. Treatment through brain grafting or reparative therapy using different nerve growth factors may be the only alternative for this disease. Researchers are still hoping that the newly discovered substances could one day help doctors treat this invincible disease and possibly cure it also.     

Implementation of BTOP funding for public computing centers: Goal consensus and project performance

This paper seeks to perform an assessment of the current state of implementation of BTOP-funded public computing center projects based on insights from principal–agent theory. Using newly available data on BTOP-funded PCC projects and correlating them with socioeconomic and geographic data derived from the US census and the FCC, we seek to assess whether program funds were targeted at unserved/underserved areas as required by program objectives, as well as the progress towards completion of PCC projects by type of grantee and funding amount. On the distribution of funds, we find that the PCCs supported were located in areas of high broadband availability as well as high demand: while this is contrary to the BTOP's stated purpose, we argue that it is actually more cost-effective to also target areas of high demand. It was also found that whereas a majority of PCC grants went to governmental agencies, who also received larger grants than non-governmental recipients, they were no more likely to generate a significantly higher percentage of matching funds or to move toward project completion sooner. We speculate that the intense competition for grants might have narrowed the performance gap between these categories of applicants.     

Governing the child-citizen: ‘Let's Move!’ as national biopedagogy

In this paper, we offer a critical examination of Let's Move!, the comprehensive anti-obesity program initiated by the First Lady of the United States, Michelle Obama, that aims to solve the problem of childhood obesity within a generation. We argue that Let's Move! is not just a campaign against obesity but is emblematic of the nature of (and assumptions underpinning) the health education of children in the contemporary United States. Drawing on the concept of ‘governmentality,’ we examine how Let's Move! functions as a biopolitical strategy (a solution to the problem of childhood obesity), framed by the political rationalities of neoliberalism. In particular, we identify and explore three interrelated bio-techniques mobilized within, and through, the Let's Move! campaign. First, in an effort to ‘responsibilize’ citizens, the initiative is framed as a social movement whereby all segments of society can (and should) be empowered to take collective action against childhood obesity. Second, an array of multi-sectoral partnerships, including corporate sponsors and non-profit organizations, are being mobilized, resulting in a range of initiatives underpinned by the rhetoric of consumer choice and responsibility as well as the outsourcing of physical education to private entities. Third, the adoption of standardized fitness testing techniques based on the logic of chronic disease epidemiology, and related notions of ‘risk,’ aim to produce the disciplined child-citizen who monitors his/her health goals with the aid of Web 2.0 technologies. In contextualizing Let's Move! in this way, we illustrate how, in line with the soft authoritarian imperatives of the neoliberal enabling state, the campaign functions as a national biopedagogy, working to empower every citizen to be an ‘active partner’ in the fight against childhood obesity, so as to optimize the health of the next generation and allow them, in the words of Michelle Obama, to ‘pursue their dreams.’     

Explicating the relationally attentive approach to conducting engaged communication scholarship

As interest in engaged communication scholarship grows, so does the need for concrete examples of how such research is done. In this essay, we articulate an example of the how by presenting the work of the Purdue Peace Project, a locally led peacebuilding initiative based at Purdue University. We do so by (a) explicating the communicative choices in our approach to engaged scholarship and (b) relating these choices to the impacts that our approach has had on preventing political violence related to a chieftaincy dispute in Keperman (pseudonym), Ghana. Based on qualitative data from multiple time points, we unpack our communicative choices, relate these choices to the realization of engagement goals and setbacks, and reveal multi-level, interdependent, and communicative indicators of impacts. We present what we term the relationally attentive approach to engaged communication scholarship and discuss implications and recommendations for those doing engaged scholarship.